Characteristic | Ciprofloxacin cohort (n = 20) | Cotrimoxazole cohort (n = 21) | p value |
---|---|---|---|
Demographic characteristics | |||
 Female gender (%) | 9 (42.9) | 9 (45) | 0.89 |
 Age, years, mean | 55.75 | 51.43 | 0.39 |
 Weight, kg, median | 80 | 78 | 0.24 |
 Height, cm, mean | 175.44 | 175.2 | 0.85 |
 Persons in household, median | 2 | 2 | 0.06 |
Underlying diseases and comorbidities | |||
 Leukemia (%) | 10 (50) | 3 (14.3) | 0.014* |
 Lymphomas (%) | 8 (40) | 19 (90.5) | 0.001* |
 Charlson Comorbidity Score, median | 2 | 2 | 0.51 |
 Glascow Coma Scale, mean | 15 | 15 | n.a. |
Baseline laboratory parameters | |||
 Creatinine, mg/dl, median | 0.75 | 0.87 | 0.004* |
 Bilirubin, mg/dl, mean | 0.65 | 0.48 | 0.01* |
 Platelets, counts/μl, median | 99,500 | 210,000 | 0.0003* |
 WBC, counts/μl, median | 5790 | 7830 | 0.06 |
 Neutrophils, counts/μl, median | 2105 | 4130 | 0.09 |
Baseline medication and medication history | |||
 Antibiotics within the last year (%) | 3 (15) | 4 (19) | 0.73 |
 Virostatic agents within the last year (%) | 0 (0) | 1 (4.8) | 0.32 |
 Anti-cancer treatment (%) | 8 (40) | 4 (19) | 0.14 |
 Virostatic agents (%) | 7 (35) | 1 (4.8) | 0.015* |
 Antifungals (%) | 6 (30) | 0 (0) | 0.007* |
 Proton pump inhibitor (%) | 8 (40) | 13 (61.9) | 0.16 |
 Cholesterol-lowering agents (%) | 3 (15) | 0 (0) | 0.07 |
 Bowel movement regulators (%) | 6 (30) | 4 (19) | 0.41 |
Baseline microbiome/resistome/plasmidome parameters | |||
 Microbiome Shannon diversity (phylum) | 0.751 | 0.808 | 0.32 |
 Microbiome evenness (phylum) | 0.0115 | 0.012 | 0.19 |
 Microbiome Shannon diversity (species) | 4.51 | 4.55 | 0.81 |
 Microbiome evenness (species) | 0.0022 | 0.0018 | 0.26 |
 Total plasmid abundance (coverage/106 reads) | 875.77 | 1066.92 | 0.06 |
 Proteobacteria plasmid abundance (coverage/106 reads) | 172.43 | 193.82 | 0.14 |
 Total plasmid Shannon diversity | 6.18 | 6.52 | 0.24 |
 Total plasmid evenness | 0.0225 | 0.0227 | 0.75 |
 Resistome Shannon diversity | 1.0048 | 1.0639 | 0.24 |
 Resistome evenness | 0.3573 | 0.3612 | 0.40 |