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Table 1 Major demographic and clinical characteristics of both treatment cohorts

From: Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study

Characteristic

Ciprofloxacin cohort (n = 20)

Cotrimoxazole cohort (n = 21)

p value

Demographic characteristics

 Female gender (%)

9 (42.9)

9 (45)

0.89

 Age, years, mean

55.75

51.43

0.39

 Weight, kg, median

80

78

0.24

 Height, cm, mean

175.44

175.2

0.85

 Persons in household, median

2

2

0.06

Underlying diseases and comorbidities

 Leukemia (%)

10 (50)

3 (14.3)

0.014*

 Lymphomas (%)

8 (40)

19 (90.5)

0.001*

 Charlson Comorbidity Score, median

2

2

0.51

 Glascow Coma Scale, mean

15

15

n.a.

Baseline laboratory parameters

 Creatinine, mg/dl, median

0.75

0.87

0.004*

 Bilirubin, mg/dl, mean

0.65

0.48

0.01*

 Platelets, counts/μl, median

99,500

210,000

0.0003*

 WBC, counts/μl, median

5790

7830

0.06

 Neutrophils, counts/μl, median

2105

4130

0.09

Baseline medication and medication history

 Antibiotics within the last year (%)

3 (15)

4 (19)

0.73

 Virostatic agents within the last year (%)

0 (0)

1 (4.8)

0.32

 Anti-cancer treatment (%)

8 (40)

4 (19)

0.14

 Virostatic agents (%)

7 (35)

1 (4.8)

0.015*

 Antifungals (%)

6 (30)

0 (0)

0.007*

 Proton pump inhibitor (%)

8 (40)

13 (61.9)

0.16

 Cholesterol-lowering agents (%)

3 (15)

0 (0)

0.07

 Bowel movement regulators (%)

6 (30)

4 (19)

0.41

Baseline microbiome/resistome/plasmidome parameters

 Microbiome Shannon diversity (phylum)

0.751

0.808

0.32

 Microbiome evenness (phylum)

0.0115

0.012

0.19

 Microbiome Shannon diversity (species)

4.51

4.55

0.81

 Microbiome evenness (species)

0.0022

0.0018

0.26

 Total plasmid abundance (coverage/106 reads)

875.77

1066.92

0.06

 Proteobacteria plasmid abundance (coverage/106 reads)

172.43

193.82

0.14

 Total plasmid Shannon diversity

6.18

6.52

0.24

 Total plasmid evenness

0.0225

0.0227

0.75

 Resistome Shannon diversity

1.0048

1.0639

0.24

 Resistome evenness

0.3573

0.3612

0.40

  1. *Statistically significant differences
  2. WBC white blood cells