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Table 1 Major demographic and clinical characteristics of both treatment cohorts

From: Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study

Characteristic Ciprofloxacin cohort (n = 20) Cotrimoxazole cohort (n = 21) p value
Demographic characteristics
 Female gender (%) 9 (42.9) 9 (45) 0.89
 Age, years, mean 55.75 51.43 0.39
 Weight, kg, median 80 78 0.24
 Height, cm, mean 175.44 175.2 0.85
 Persons in household, median 2 2 0.06
Underlying diseases and comorbidities
 Leukemia (%) 10 (50) 3 (14.3) 0.014*
 Lymphomas (%) 8 (40) 19 (90.5) 0.001*
 Charlson Comorbidity Score, median 2 2 0.51
 Glascow Coma Scale, mean 15 15 n.a.
Baseline laboratory parameters
 Creatinine, mg/dl, median 0.75 0.87 0.004*
 Bilirubin, mg/dl, mean 0.65 0.48 0.01*
 Platelets, counts/μl, median 99,500 210,000 0.0003*
 WBC, counts/μl, median 5790 7830 0.06
 Neutrophils, counts/μl, median 2105 4130 0.09
Baseline medication and medication history
 Antibiotics within the last year (%) 3 (15) 4 (19) 0.73
 Virostatic agents within the last year (%) 0 (0) 1 (4.8) 0.32
 Anti-cancer treatment (%) 8 (40) 4 (19) 0.14
 Virostatic agents (%) 7 (35) 1 (4.8) 0.015*
 Antifungals (%) 6 (30) 0 (0) 0.007*
 Proton pump inhibitor (%) 8 (40) 13 (61.9) 0.16
 Cholesterol-lowering agents (%) 3 (15) 0 (0) 0.07
 Bowel movement regulators (%) 6 (30) 4 (19) 0.41
Baseline microbiome/resistome/plasmidome parameters
 Microbiome Shannon diversity (phylum) 0.751 0.808 0.32
 Microbiome evenness (phylum) 0.0115 0.012 0.19
 Microbiome Shannon diversity (species) 4.51 4.55 0.81
 Microbiome evenness (species) 0.0022 0.0018 0.26
 Total plasmid abundance (coverage/106 reads) 875.77 1066.92 0.06
 Proteobacteria plasmid abundance (coverage/106 reads) 172.43 193.82 0.14
 Total plasmid Shannon diversity 6.18 6.52 0.24
 Total plasmid evenness 0.0225 0.0227 0.75
 Resistome Shannon diversity 1.0048 1.0639 0.24
 Resistome evenness 0.3573 0.3612 0.40
  1. *Statistically significant differences
  2. WBC white blood cells