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Table 2 Multivariate selection pressure estimates for major antibiotic resistance gene classes

From: Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study

ARG class Ciprofloxacin coefficient Ciprofloxacin coefficient (normalized) Cotrimoxazole coefficient Cotrimoxazole coefficient (normalized) LR p value (likelihood ratio test)
Aminoglycoside ARGs − 0.4 − 4.44% 1.45 8.16% < 0.0001
Beta-lactamases 0.73 1.63% − 7.44 − 10.39% 0.04
CTX-M 0.05 50% − 0.02 − 40% < 0.0001
Fluoroquinolone ARGs − 0.001 − 0.14% 0.15 10.06% 0.79
Glycopeptide ARGs 0.04 2.48% − 0.11 − 5.88% < 0.0001
MLS ARGs 4.22 4.23% 7.76 10.25% < 0.0001
Nitroimidazole ARGs − 0.0008 − 10.52% − 0.006 − 25% < 0.0001
Phenicol ARGs − 0.06 − 6.52% 0.56 31.11% < 0.0001
Sulfonamide ARGs − 0.13 − 5.03% 2.34 148.1% < 0.0001
Tetracycline ARGs 4.57 3.05% − 2.52 − 1.45% 0.94
Trimethoprim ARGs − 0.004 − 2.5% 0.86 477.77% < 0.0001
  1. ARG antibiotic resistance gene, CTX-M plasmid-mediated cefotaximases, MLS macrolide-lincosamide-streptogramin
  2. Normalized coefficients are based on the mean baseline ARG length-corrected relative abundance (LCRA) and demonstrate a relative change in ARG LCRA per defined daily dose (DDD) of the antibiotic