Table 2 Multivariate selection pressure estimates for major antibiotic resistance gene classes
ARG class | Ciprofloxacin coefficient | Ciprofloxacin coefficient (normalized) | Cotrimoxazole coefficient | Cotrimoxazole coefficient (normalized) | LR p value (likelihood ratio test) |
|---|---|---|---|---|---|
Aminoglycoside ARGs | − 0.4 | − 4.44% | 1.45 | 8.16% | < 0.0001 |
Beta-lactamases | 0.73 | 1.63% | − 7.44 | − 10.39% | 0.04 |
CTX-M | 0.05 | 50% | − 0.02 | − 40% | < 0.0001 |
Fluoroquinolone ARGs | − 0.001 | − 0.14% | 0.15 | 10.06% | 0.79 |
Glycopeptide ARGs | 0.04 | 2.48% | − 0.11 | − 5.88% | < 0.0001 |
MLS ARGs | 4.22 | 4.23% | 7.76 | 10.25% | < 0.0001 |
Nitroimidazole ARGs | − 0.0008 | − 10.52% | − 0.006 | − 25% | < 0.0001 |
Phenicol ARGs | − 0.06 | − 6.52% | 0.56 | 31.11% | < 0.0001 |
Sulfonamide ARGs | − 0.13 | − 5.03% | 2.34 | 148.1% | < 0.0001 |
Tetracycline ARGs | 4.57 | 3.05% | − 2.52 | − 1.45% | 0.94 |
Trimethoprim ARGs | − 0.004 | − 2.5% | 0.86 | 477.77% | < 0.0001 |