Fig. 1From: Cold-induced lipid dynamics and transcriptional programs in white adipose tissueChanges of the overall lipid composition and distribution in iWAT in response to cold exposure. Lipidomic analysis of iWAT isolated from mice maintained at room temperature (RT, 22 °C) or cold (4 °C) for 3 days. Lipids were extracted and analyzed as described in the “Methods” section. a Distribution of lipid classes that were considered for subsequent analysis in all of the samples detected by LC-MS/MS. b–g The intensity fold change of fatty acyls (b), glycerolipids (c), glycerophospholipids (d), sphingolipids (e), saccharolipids (f), and prenol lipids (g). Data are presented as means + SEM (n = 8). *P < 0.05, ***P < 0.001. h Log2 fold changes in lipid species in cold-treated versus RT mice and the corresponding significance values displayed as -log10 (P value). Each dot represents a lipid species, and the dot size indicates significance. Only lipids with P < 0.05 are displayed (n = 8)Back to article page