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Fig. 5 | BMC Biology

Fig. 5

From: Cold-induced lipid dynamics and transcriptional programs in white adipose tissue

Fig. 5

Cold exposure changes the composition of sphingolipids. a The top 20 sphingolipids according to the P value, detected in iWAT from RT- and cold-treated mice (n = 8). b, c The total intensity fold changes of individual fatty-acyl chains associated with ceramides (CER) and sphingomyelin (SM) sorted by degree of saturation. SAF, saturated fatty acyls; MUFA, monounsaturated fatty acyls; PUFA, polyunsaturated fatty acyls containing two or three to six double bonds; ODD, odd-numbered fatty acyls. The transparency of each bar is proportional to the significance values, which are displayed as -log10 (P value). The gray bars indicate those with P > 0.05. d The total intensity fold changes of individual fatty-acyl chain associated with ceramides So. e RNA-seq reveals relatively expression of genes involved in sphingomyelin biogenesis and breakdown. Data are presented as means + SEM (n = 4–5). f Selected sphingolipid metabolic reactions from KEGG, with indications of quantified lipid classes and acyl chains (circles) and genes (rectangles) significantly regulated in iWAT by short-term cold exposure. For other abbreviations, see Fig. 2

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