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Fig. 3. | BMC Biology

Fig. 3.

From: Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico

Fig. 3.

The filament tilt determines the shape and sign of the membrane deformation. Overview of the two-state model, providing examples for different outcomes. a In the flat state, the target geometry is a planar ring with the membrane attraction sites facing downwards (τ=0) and the filament is observed as a flat spiral. By internally rotating the target geometry ring, we enter the tilted state in which tubules develop for τ=90, cones for 0<τ<90, everted cones for τ<0, and everted tubules for τ=−90. b The buckle depth dependence on the target radius R and the angle τ of the tilted state. Each simulation started off with the same initial spiral in the flat state with persistence length lp=1.8·103 nm. c The buckle depth dependence on the target radius R and the persistence length lp of the tilted state (τ=60). Each simulation started off with the same initial spiral in flat state. The insets show snapshots of the representative cases

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