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Fig. 3 | BMC Biology

Fig. 3

From: The intestinal microbiota regulates host cholesterol homeostasis

Fig. 3

Enterohepatic cycle of cholesterol and bile acids in conventionally raised and microbiota-depleted mice. a Bile volume collected in 1 h of gallbladder cannulation in conventionally raised (Conv-R) and microbiota-depleted mice (AB-Mdpl). b Quantity of cholesterol secreted in the bile during 1 h of gallbladder cannulation. c Hepatic gene expression of enzymes involved in bile acid biosynthesis and of transporters of cholesterol and bile acids in conventionally raised (Conv-R) and microbiota-depleted mice (AB-Mdpl). d Fecal excretion of 14C bile acids (water-soluble fraction) and 14C cholesterol (cyclohexane soluble fraction) during 72 h after oral gavage with 14C cholesterol. e 14C bile acids excreted in the feces expressed as percent of total radioactivity (cholesterol + bile acids). f Relative expression of fgf15 in the distal ileum. g Plasma radioactivity 2 h after gavage with [3H]-taurocholic acid. h Relative gene expression of bile acid transporters in the distal ileum. Data are represented as mean ± SEM (c, f, h) or as dots with median (a, b, g), n = 5–8 mice/group. Data were analyzed with Mann–Whitney test. *p < 0.05, **p < 0.01, ***p < 0.001

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