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Fig. 5 | BMC Biology

Fig. 5

From: The intestinal microbiota regulates host cholesterol homeostasis

Fig. 5

Intestinal microbiota regulates cholesterol absorption/synthesis balance. a Relative expression of genes related to cholesterol absorption and lipoprotein secretion in the jejunum in mice colonized with the microbiota from normocholesterolemic donors (NorChol-r1 and r2, pictured cyan and dark cyan) and high-cholesterol donors (HiChol-r1 and r2, pictured in red and dark red). b Relative expression of enzymes involved in cholesterol synthesis in the liver. See also Additional file 9: Figure S4. c Cholesterol and lathosterol concentration analyzed by GC-MS in the liver. d Triglycerides and phospholipids analyzed by biochemic assay in the liver. e Hepatic relative expression of LDLr. f Hepatic relative expression of Cyp7a1 in the liver. g Relative expression of fgf15 in the distal ileum. Data are represented as mean ± SEM (a, b, e, f, g) or as dots with median (c, d), n = 8–12 mice/group. Recipient groups were analyzed using Kruskal–Wallis test followed by Dunn’s pairwise multiple comparison procedure. *q < 0.05, **q < 0.01, ***q < 0.001

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