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Fig. 7 | BMC Biology

Fig. 7

From: The intestinal microbiota regulates host cholesterol homeostasis

Fig. 7

Microbial regulation of whole-body cholesterol fluxes and enterohepatic cycle. Microbiota depletion in Apoe−/− mice raises plasma VLDL and LDL cholesterol. Microbiota-depleted mice have increased intestinal cholesterol absorption, hepatic cholesterol uptake, and hepatic cholesterol and bile acid synthesis. Bile secretion is also increased in microbiota-depleted mice, which is associated with increased fecal excretion of bile acids. Microbiota depletion is associated with a decrease in fgf15 expression in the distal ileum, thus alleviating feedback inhibition of hepatic bile acid synthesis

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