Fig. 7.

CTCF motif density and local interaction score within and around TADs. Local interaction score across any position measured from Hi-C matrices and represented on the y-axis (left). The mean density of predicted CTCF binding sites is also shown on the y-axis (right). Mean interaction score and CTCF density are plotted relative to the positions of Hi-C-derived Topologically Associating Domains. Dotted lines indicate TAD boundaries. Absolute scale is used on the x-axis up to 0.5 Mb on each side of the TADs while relative positions are used inside the domains (from 0 to 100% of the TAD length)