Fig. 8.

Gene expression (a) and chromatin accessibility (b) in A and B topological compartments. For the three species with Hi-C-derived A and B compartments, the distribution of the RNA-seq gene expression values (normalized read counts, top panel) and ATAC-seq chromatin accessibility values (normalized read counts, bottom panel) is shown per compartment type. A “active” compartments. B “repressed” compartments. As Hi-C data was only available from liver, only RNA-seq and ATAC-seq values from the same samples were considered. The significant and systematic difference of gene expression and chromatin accessibility values between A and B compartments (p values <2.2×10⁻¹⁶ overall, Wilcoxon tests) confirms a general consistency between RNA-seq, ATAC-seq and Hi-C data across species