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Fig. 4 | BMC Biology

Fig. 4

From: Crossing fitness valleys via double substitutions within codons

Fig. 4

Selective regimes of the codon double substitutions. The panels on the left show the comparison of each codon double substitution class to the double synonymous null models, and the panels to the right show the comparisons between the DF of each of the classes in fast vs. slow evolving genes. Purple, NM1; gray, NM2; light green, NS; yellow, SS; light orange, SN; light blue, NN. b NS, one non-synonymous intermediate, synonymous final codon. t test with NM1 p value = 1.92 × 10−09, U test with NM1 p value = 4.40 × 10−05, t test with NM2 p value = 1.11 × 10−27, U test with NM2 p value = 1.12 × 10−06. b SS, double synonymous codon substitutions. t test with NM1 p value = 0.25, U test with NM1 p value = 0.13, t test with NM2 p value = 0.007, U test with NM2 p value = 0.02. c SN, at least one synonymous intermediate codon, non-synonymous final codon. t test with NM1 p value = 9.73 × 10−127, U test with NM1 p value = 8.17 × 10−70, t test with NM2 p value = 7.72 × 10−232, U test with NM2 p value = 2.7 × 10−177. d NN, both intermediates and the final codon are non-synonymous to the ancestral. t test with NM1 p value = 0.14, U test with NM1 p value = 0.94, t test with NM2 p value = 1.45 × 10−07, U test with NM2 p value = 0.19

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