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Fig. 8. | BMC Biology

Fig. 8.

From: The round goby genome provides insights into mechanisms that may facilitate biological invasions

Fig. 8.

The inflammasome pathway. Pathogen-associated patterns are recognized by pattern recognition receptors such as Toll-like receptors at the cell surface (TLRs), or NACHT domain and Leucine-rich Repeat containing receptor (NLRs) in the cytoplasm. This interaction triggers the transcription of cytokine precursors via NFkB, and the activation and assembly of inflammasome components (NLRs, Pro-Caspase-1, and ASC). Inflammasome-activated Caspase 1 then initiates the maturation of cytokines and an acute phase inflammatory response (CRP, APCS proteins), and/or pyroptosis through gasdermin. Several components of the pathway are expanded in the round goby (gene numbers in round goby, or novel groups for NLRs, are indicated in orange)

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