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Fig. 6 | BMC Biology

Fig. 6

From: Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

Fig. 6

AβO1–42 causes dysfunction of SST interneuron-mediated disinhibition to CA1 PC. a, b Experimental setup for whole-cell voltage-clamp recordings of IPSCs in CA1 PC during theta-nested gamma oscillation-like tLTP induction. CA1 PC spikes were elicited by stimulating the CA1 PC axons in CA1 alveus. c IPSCs evoked by SC stimulation alone (black) and pairing of SC stimulation with alveus stimulation in DMSO-treated slices (gray). Disinhibition was measured by the difference in IPSCs amplitudes of the two conditions. d Same as c but in AβO1–42-treated slices. e, f Same as a–c but with activation of ChR2-expressing SST interneuron (ChR2-SST) with blue light (470 nm) in AβO1–42-treated slices. g Comparison of disinhibition of IPSCs amplitude in DMSO-treated (black), AβO1–42-treated slices (red) and with activation of ChR2-SST interneuron in AβO1–42-treated slices (blue). One-way ANOVA with post hoc Tukey’s test (g, #p < 0.05, ns: not significant). Data are represented as mean ± SEM

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