TY - JOUR AU - Lundin, Elin AU - Wu, Chenglin AU - Widmark, Albin AU - Behm, Mikaela AU - Hjerling-Leffler, Jens AU - Daniel, Chammiran AU - Öhman, Marie AU - Nilsson, Mats PY - 2020 DA - 2020/01/14 TI - Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation JO - BMC Biology SP - 6 VL - 18 IS - 1 AB - Adenosine-to-inosine (A-to-I) RNA editing is a process that contributes to the diversification of proteins that has been shown to be essential for neurotransmission and other neuronal functions. However, the spatiotemporal and diversification properties of RNA editing in the brain are largely unknown. Here, we applied in situ sequencing to distinguish between edited and unedited transcripts in distinct regions of the mouse brain at four developmental stages, and investigate the diversity of the RNA landscape. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-019-0736-3 DO - 10.1186/s12915-019-0736-3 ID - Lundin2020 ER -