Fig. 6
From: Multiple links between 5-methylcytosine content of mRNA and translation
Individual mRNA candidate m5C sites showing significant correlation of cytosine non-conversion with translation state. Dual axis charts show cytosine non-conversion (bars) and coverage (red lines) for a given site across the polysome gradient. Data is shown as means across biological triplicates, with error bars indicating standard deviation. Asterisks indicate significance p values after logistic regression testing (see key below the charts). The gene name for each candidate site and its position within the mRNA is given. All sites shown here show significant negative non-conversion change in at least two fraction steps and are represented in the F1234 clustering with the cluster number indicated in brackets. mRNAs shown are as follows: SERP1 (stress associated endoplasmic reticulum protein 1); GID8 (GID complex subunit 8 homologue); TALDO1 (transaldolase 1); KRT17 (keratin 17); RPS3 (ribosomal protein S3); CCT5 (chaperonin containing TCP1 subunit 5); GIPC1 (GIPC PDZ domain containing family member 1); COPS5 (COP9 signalosome subunit 1); LRP11 (LDL receptor related protein 11); TRAF7 (TNF receptor associated factor 7); CD63 (CD63 molecule); RCC1L (RCC1-like)