Fig. 5

Overview of the significantly different predicted net metabolite production potentials (NMPCs) of microbial communities from PD patients and healthy individuals. a Box plots for NMPC differential between cases and controls with FDR < 0.05. b Box plots for NMPCs with sex-specific PD signature or constipation effects (all FDR < 0.05). c Scatter plot of non-motor symptom scores and the NMPC of pantothenic acid displaying the regression lines for cases and controls. The slope was significantly bigger than zero (FDR < 0.05). d Scatter plot of cysteine-glycine NMPC and age for cases and controls displaying the corresponding regression lines. The difference in slopes of regression lines was significant (FDR < 0.05). FDR, false discovery rate