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Fig. 2 | BMC Biology

Fig. 2

From: Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans

Fig. 2

Analysis of C. albicans heterozygosity patterns. a Schematic phylogenetic tree adapted from [40] indicating the different C. albicans clades in orange. The potential common ancestor is marked with a red dot. Strains used for the comparison of heterozygous positions across different clades are indicated, with strains of the same group of analysis being written with the same color (black—group 1, blue—group 2, and gray—group 3). b Schematic representation of the methodology for the comparison of heterozygous SNPs in heterozygous blocks (gray). The intersection of the heterozygous blocks is represented by the red rectangle (although not shown, the same approach was used for the analysis of LOH blocks). Examples of possible combinations of genotypes across the four strains are given (“0”—allele similar to the reference, “1”—allele different from the reference, “2”—allele different from the reference and from “1”). The most parsimonious path for the SNPs observed in each position was reconstructed. The decision taken for each position in a given strain is represented by yellow (recent), blue (ancestral), or gray (ambiguous) spheres. c Plot of the average proportion of ambiguously (gray) and unambiguously assigned positions for each group of strains. For unambiguously assigned positions, the proportion of recent and ancestral positions is shown in yellow and blue, respectively. d Maximum likelihood phylogeny of the aligned reconstructed haplotypes A and B for the intersection of heterozygous blocks > 100 bp of group 1. e Sequence divergence distribution in heterozygous blocks of C. albicans SC5314, CEC4492, CEC4497, and CEC5026

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