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Fig. 3 | BMC Biology

Fig. 3

From: Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans

Fig. 3

Schematic representation of plausible scenarios for the origin of C. albicans heterozygosity. a The scenario proposed by this work is presented on the left, showing an ancestral hybridization event between two diverged lineages as the main source of C. albicans heterozygosity, followed by LOH, particularly extensive in C. africana, and more recent exchange of genomic material between C. albicans strains (dashed lines). The alternative scenario is presented on the right, showing inter-strain recombination (dashed lines) as the only explanation for the heterozygous patterns observed in C. albicans. b Scheme of the expected sequence divergence patterns between the two haplotypes if a single hybridization event was in the origin of the heterozygosity in C. albicans. After a hybridization event, the heterozygous blocks are expected to have similar sequence divergence, which is then reflected in a normal distribution. This divergence is expected to be similar in all strains originated from the same event. c Scheme of the expected sequence divergence patterns if inter-strain recombination was the only source of variability in C. albicans. In this scenario, the sequence divergence is time and strain dependent, and therefore, different patterns are expected between different blocks and between different strains

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