Fig. 1

S10 location impacts cell physiology. a General bacterial genome structure: the oriC (red dot) determines two symmetric replichores along the ori-ter axis (left panel). When bacteria grow slowly, genes have 1 to 2 copies (center). During exponential growth, fast growers overlap replication rounds increasing the dosage of oriC-neighboring regions (right panel). The approximate position of the S10 locus is shown by an arrow. b The maximum growth rate (μ) and the relative S10 dosage and expression with respect to the parental strain plotted as a function of S10 position along the ori-ter axis within V. cholerae genome. c Genome structure of the parental, the movant, and the merodiploid strains employed in this study. The orange arrow represents S10 displaying its genomic position and ploidy. The dashed line represents the S10 location in the parental strain. Chromosomes are drawn according to their replication timing