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Fig. 2 | BMC Biology

Fig. 2

From: Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Fig. 2

Examples of CHi-C interactions in gene deserts implicating distal/novel genes. Interactions are shown in the 2p15 (B3GNT2) locus (a) and the 1p36.23 (RERE, SLC45A1, ERRFI1, TNFRSF9) locus (b). The tracks include psoriasis (Ps) LD blocks as defined by SNPs in r2 > 0.8 with the index SNP, baited HindIII fragments, RefSeq genes (NCBI), H3K27ac and H3K4me3 P value signal in NHEK (ENCODE) and CD8+ primary naive T cells (Roadmap Epigenomics), TADs (shown as bars) and CHi-C interactions significant at CHiCAGO score ≥ 5 (shown as arcs) in three conditions: unstimulated HaCat cells (purple), HaCaT cells stimulated with IFN-γ (red) and My-La cells (blue). The highlighted region indicates the psoriasis LD block. The figure was made with the WashU Epigenome Browser, GRCh37/hg19 [31]

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BMC Biology

ISSN: 1741-7007

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