Fig. 5

HiChIP (H3K27ac) interactions with the KLF4 promoter in the 9q31.2 locus. The tracks include psoriasis LD block as defined by SNPs in r² > 0.8 with rs10979182, RefSeq genes, TADs (shown as bars), H3K27ac occupancy (shown as peaks) and significant HiChIP interactions (shown as arcs) in three conditions: unstimulated HaCaT cells (purple), HaCaT cells stimulated with IFN-γ (red) and My-La cells (blue). The HiChIP interactions were restricted to those originating either from the psoriasis SNPS or the KLF4 promoter. The yellow highlighted region indicates the psoriasis LD block at rs10979182. The purple highlighted region indicates the previously described KLF4-interacting region in the breast cancer study [17]. The scales in the HiChIP interactions represent the FitHiChIP score. The figure was made with the WashU Epigenome Browser, GRCh37/hg19 [31]