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Fig. 6 | BMC Biology

Fig. 6

From: Discordant evolution of mitochondrial and nuclear yeast genomes at population level

Fig. 6

Natural variation in mitochondrial genome copy number. a Mitochondrial genome copy number linearly increase with the nuclear genome content. Fifteen natural petite isolates were detected. The number of isolates is indicated above the corresponding plot. b Spotting assay on non-fermentable carbon source (YPEG) confirms natural petite isolates (a subset of tested isolates is shown). c Mitochondrial activity (as membrane potential) is strongly altered by the lack of mitochondrial genome (black versus grey symbols), while the volume remains unaltered. d Growth curve variation of isogenic strains with normal mitochondria (rho+, red), petite (rho0, green) and petite harbouring the ATP2G1099T suppressing mutation (rho0 ATP2 sup, blue). Among natural petites, we can identify both isolates with high doubling time (DT, black solid line) and isolates with recovered growth rate, comparable to petite with suppressor mutations (black dashed line). e Generation times for isolates with different mitochondrial CN show at least two natural petite isolates that seem to have recovered normal growth rate on rich media. Growth curves for the circled isolates are shown in d

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