Fig. 2

Cross-species mapping of epigenome data and validation of predicted epigenomes. a Transferring efficiency of eight histone marks from human to cattle using CrossMap. b Enriched Gene Ontology (GO) terms for genes that are not transferred from human (H3K4me3) to cattle (human-specific) and genes that are not covered by transferred epigenome (H3K4me3) in cattle (cattle-specific). c Venn plots for overlaps between length of transferred H3K4me3 peaks and that of measured ones in liver and muscle, respectively. d Enriched GO terms for genes with tissue-specific histone marks (H3K4me3) in six tissues. e Heat-map plot for correlations of t-statistics of genes based on expression and H3K4me3 signals (Methods). X-axis: tissues for gene expression. Y-axis: tissues for H3K4me3 signals. “*” denotes significant positive correlations after FDR correction (FDR < 0.001). f Heat-map plot for correlation of t-statistics of genes based on promoter DNA methylation and H3K4me3 signals. X-axis: tissues for promoter DNA methylation. Y-axis: tissues for H3K4me3 signals. “*” denotes significant positive correlations after FDR correction (FDR < 0.001). g An example of gene (INHBC) with liver-specific H3K4me3 signal. UCSC tracks included transferred H3K27ac, H3K4me3, H3K9ac, H3K36me3, and measured DNA methylation (Meth) data in cattle. Bottom is the gene expression (FPKM) of INHBC across 91 bovine tissues