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Fig. 4 | BMC Biology

Fig. 4

From: Comparative whole genome DNA methylation profiling across cattle tissues reveals global and tissue-specific methylation patterns

Fig. 4

Classifications of TSS-HMR and their tissue specificity. a Classification of the 5 types of the TSS-HMR: (1) no-TSS-HMR; (2) total in HMR; (3) TSS-HMR T1; (4) TSS-HMR T2; (5) TSS-HMR T3. Please refer to the main text for details. b Comparison of the methylation-level correlation of the CG with different distances between the TSS-HMR core region and two flank regions. c Boxplots of the gene expression for the genes with TSS-HMR or not. d Correlation analysis of the expression of the gene pairs with TSS located in the same HMR. Random: same number of genes pairs randomly chosen from all genes; control: same number of gene pairs randomly chosen from all genes with the same distance of the two TSS; Same_HMR: the gene pairs with TSS located in the same HMR. e The consistent ratio of gene pairs with TSS located in the same HMR of cattle in the other species, we defined the nearest two different strands genes as gene pairs. f The example of TP63: its tissue-specific expression of different transcripts from the two different TSS were regulated by the two tissue-specific TSS-HMRs. g Heatmap of the methylation level of tissue-specific TSS-HMR. h Heatmap of the expression levels of the genes showing tissue-specific high expression and tissue-specific TSS-HMR. i Transcription factor binding motif enrichment analyses of the tissue-specific TSS-HMR using the liver as an example

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