Fig. 4

Disinhibition shapes different network properties in WT or HD mouse models. a Representative examples of WT and HD striatal effective connectivity matrices after disinhibition with BIC 60 μM. Color boxes highlight communities. b–e Change in network properties for cultures before and after disinhibition. b Global efficiency, c average community size, d community statistic Q, and e average number of connector hubs. Each circle represents a single experiment (STR WT n = 8; STR HD n = 9; CTX WT n = 19; CTX HD n = 22), thick line the mean, thick shaded area the standard error of the mean, and thin shaded area the standard deviation. Statistical analysis was performed using mixed ANOVA and posterior post hoc test with Bonferroni’s multiple comparison correction. Only * for the post hoc test are shown, *p < 0.05, **p < 0.01, ***p < 0.001