Fig. 6

NMDA treatment restores neuronal network topology in striatal HD cultures. a Representative examples of WT and HD striatal effective connectivity matrices after NMDA 10 μM. Color boxes highlight communities. b–e Change in network properties for cultures before and after NMDA treatment. b Global efficiency, c average community size, d community statistic Q, and e average number of connector hubs. Each circle represents a single experiment (STR WT n = 10; STR HD n = 7), thick line the mean, thick shaded area the standard error of the mean, and thin shaded area the standard deviation. Statistical analysis was performed using mixed ANOVA and posterior post hoc test with Bonferroni’s multiple comparison correction. Only * for the post hoc test are shown, *p < 0.05, **p < 0.01, ***p < 0.001