TY - JOUR AU - Özugur, Suzan AU - Kunz, Lars AU - Straka, Hans PY - 2020 DA - 2020/07/03 TI - Relationship between oxygen consumption and neuronal activity in a defined neural circuit JO - BMC Biology SP - 76 VL - 18 IS - 1 AB - Neuronal computations related to sensory and motor activity along with the maintenance of spike discharge, synaptic transmission, and associated housekeeping are energetically demanding. The most efficient metabolic process to provide large amounts of energy equivalents is oxidative phosphorylation and thus dependent on O2 consumption. Therefore, O2 levels in the brain are a critical parameter that influences neuronal function. Measurements of O2 consumption have been used to estimate the cost of neuronal activity; however, exploring these metabolic relationships in vivo and under defined experimental conditions has been limited by technical challenges. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-020-00811-6 DO - 10.1186/s12915-020-00811-6 ID - Özugur2020 ER -