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Fig. 5 | BMC Biology

Fig. 5

From: FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling

Fig. 5

Inhibiting FGFR2b rescued the supernumerary tooth phenotype. a The schematic depicts the rescue strategy of supernumerary tooth formation by inhibiting FGFR2b with a dominant-negative FGFR2b inhibitor through a tetO system. The K14rtTA, tetOFGFr2b/Igh, and K14Cre/+;Fam20Bfl/fl mice were crossbred to ultimately generate K14rtTA;tetOFGFr2b/Igh;K14Cre/+;Fam20Bfl/fl mice. Doxycycline was administrated to the resultant mice at 2 mg/kg at designated time points (E10.5–E14.5) to induce the expression of the dominant-negative FGFR2b inhibitor, FGFR2b/Igh, in the GAG-deficient dental epithelium. be Inhibiting FGFR2b in the dental epithelium fully (D) or partially (E) rescued the supernumerary tooth phenotype in the K14Cre/+;Fam20Bfl/fl mice

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