Fig. 5

Inhibiting FGFR2b rescued the supernumerary tooth phenotype. a The schematic depicts the rescue strategy of supernumerary tooth formation by inhibiting FGFR2b with a dominant-negative FGFR2b inhibitor through a tetO system. The K14^rtTA, tetO^FGFr2b/Igh, and K14^Cre/+;Fam20B^fl/fl mice were crossbred to ultimately generate K14^rtTA;tetO^FGFr2b/Igh;K14^Cre/+;Fam20B^fl/fl mice. Doxycycline was administrated to the resultant mice at 2 mg/kg at designated time points (E10.5–E14.5) to induce the expression of the dominant-negative FGFR2b inhibitor, FGFR2b/Igh, in the GAG-deficient dental epithelium. b–e Inhibiting FGFR2b in the dental epithelium fully (D) or partially (E) rescued the supernumerary tooth phenotype in the K14^Cre/+;Fam20B^fl/fl mice