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Fig. 2 | BMC Biology

Fig. 2

From: Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model

Fig. 2

Supernumerary GFI axonal projections in dfmr150M null mutants. a The giant fiber interneuron (GFI) visualized with 91H05-Gal4 driving the membrane marker UAS-mcd8::gfp (green) in the w1118 genetic background control (left) and the dfmr150M null mutant (right). In the controls, GFI axonal bends have relatively few projections compared to an excess number of overgrown projections in the mutants. Arrows indicate representative axon projections. b Iontophoretic TRITC-dextran dye injection (magenta) in w1118 (left) and dfmr150M (right) stocks show the same projection phenotype. Scale bars, 5 μm. c Quantification of the GFP-labeled axonal projections. Each gray dot represents the average projection number of both bends in one animal. The black dot represents the average, and the red bars represent the standard error of the mean. Sample sizes: w1118 (n = 8) and dfmr150M (n = 8) animals. d Quantification of the TRITC-labeled projections. Each gray dot represents an axon bend in one animal. Sample sizes: w1118 (n = 62) and dfmr150M (n = 48)

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