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Fig. 3 | BMC Biology

Fig. 3

From: Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

Fig. 3

Comparison of binding modes of N12-i2 and CCR5 co-receptor to HIV-1 Env gp120. N12-i2 Fab-gp12093TH057 coree-M48U1 and CCR5-gp120-CD4d1d4 (PDB code 6MET) complex structures are superimposed based on gp120 outer domain. The N12-i2 Fab is displayed over the CCR5-gp120-CD4d1d4 complex (CCR5 shown as ribbon diagram and the molecular surface is displayed over gp120 and CD4). The TYS of N12-i2 and CCR5 are indicated by red arrows. The blow-up views show details of the TYS binding sites. The hydrogen bond network formed at TYS100B of N12-i2 and Tyr15 of CCR5 is shown with dotted lines

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