Fig. 6.
From: Genome-wide pQTL analysis of protein expression regulatory networks in the human liver
Protein regulatory networks for DECR1 and PSMD4. Protein regulatory networks for DECR1 and PSMD4 (a). The predicted regulators include protein-coding genes and non-coding RNA genes significantly enriched with pQTL variants (Bonferroni-adjusted p value < 0.05). Predicted regulator nodes are formatted as “regulator: gene name”. Co-regulation of DECR1 and PSMD4 in human livers (b). Chromosome positions of NBN, DECR1, and PSMD4 (b, top-left). Genomic region enrichment analysis predicted NBN to be a regulator of DECR1 and PSMD4. Protein levels of DECR1 and PSMD4 were highly correlated in human livers (b, top-right). Manhattan plots of pQTL variants associated with DECR1 (b, bottom-left) and PSMD4 (b, bottom-right). The missense variant rs1805794 of NBN is in a binding site of the HOXB2::NHLH1 transcription factor complex (b, top-left). The rs1805794 was also one of the top pQTL variants significantly associated with the protein expressions of DECR1 (b, bottom-left) and PSMD4 (b, bottom-right)