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Fig. 2. | BMC Biology

Fig. 2.

From: Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility

Fig. 2.

The effect of engineered paternal male bias on the performance of the drive allele, based on the non-spatial (lines) and spatial (dots) models. The three drive alleles differ in somatic expression, so that heterozygous females have a fertility cost of 0 (‘no cost’), 0.7 (‘medium cost’), and 0.8 ‘high cost’ (chosen to result in three equally spaced levels of population suppression in the absence of paternal male bias, cf. Figure 1b; parental costs are not considered). For the spatial model, population suppression is computed after 8 years of releases following a release strategy as defined in Fig. 1

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