Fig. 2

Driver mutations are both private and shared between matched adenoma-carcinoma samples. a High-depth panel sequencing results of 100 most commonly altered CRC genes. Mutations in samples are public (gray) if the identical mutation is found in both the adenoma and the carcinoma belonging to one sample (matched samples). Mutations found exclusively in the adenoma or the carcinoma are “private” and depicted in orange or red, respectively (see insert on the right for color depiction). Each column represents one sample with matched adenoma and carcinoma tissue. Four samples which contained no private mutations were further re-sequenced by whole-exome sequencing (WES; arrows). Samples are grouped according to cancer stage at the time of isolation. b Samples grouped according to adenoma grade (low- and high-grade dysplasia) from each sample, only alterations found in the adenoma are displayed (that is, public and adenoma-private mutations, in gray and orange, respectively) (see insert bottom right for color depiction). Note: only microsatellite stable (MSS) samples are displayed. Only non-synonymous mutations are displayed