Table 1 Summary of F0 rabbits generated in this study
From: Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions
| Â | Â | Â | Â | Mutant ratio (%) | ||
|---|---|---|---|---|---|---|
System | Target site | Embryos transferred | No. of offspring | No. of mutants | No. of homozygous mutants | No. of bystander mutants |
eA3G-BE | Tyr-1 p.Q48Stop | 42 | 6 | 5 (83) | 3 (50) | 0 (0) |
eA3G-NG | Tyr-4 p.W218Stop | 38 | 5 | 5 (100) | 5 (100) | 0 (0) |