TY - JOUR AU - Woodling, Nathaniel S. AU - Rajasingam, Arjunan AU - Minkley, Lucy J. AU - Rizzo, Alberto AU - Partridge, Linda PY - 2020 DA - 2020/09/14 TI - Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling JO - BMC Biology SP - 124 VL - 18 IS - 1 AB - The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse animal species, but with trade-offs including delayed development. It is possible that distinct cell types underlie effects on development and ageing; cell-type-specific strategies could therefore potentially avoid negative trade-offs when targeting diseases of ageing, including prevalent neurodegenerative diseases. The highly conserved diversity of neuronal and non-neuronal (glial) cell types in the Drosophila nervous system makes it an attractive system to address this possibility. We have thus investigated whether IIS in distinct glial cell populations differentially modulates development and lifespan in Drosophila. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-020-00854-9 DO - 10.1186/s12915-020-00854-9 ID - Woodling2020 ER -