Skip to main content
Fig. 4. | BMC Biology

Fig. 4.

From: Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

Fig. 4.

Effects of single and multiple base substitutions and the nucleobase position in the codon. a–d ΔΔG distribution (in kcal/mol) of amino acid mutations in \(\mathcal {M}_{\text {PoP}}\). a μSBSs and μMBSs in the core (RSA ≤20%) and b on the surface (RSA >20%). c μSBSs resulting from substitutions of bases I, II, or III in the codon. d μMBSs resulting from simultaneous substitutions of two or three bases in the codon. Ratio of stabilizing, destabilizing, and neutral mutations considering random mutations (that occur with equal frequency at each codon position) e, or considering translation errors (that occur with different frequency at each codon position) f. Note that in e, f, the synonymous mutations and mutation degeneracy are included in the computations

Back to article page