Skip to main content

Table 7 Difference between 〈ΔΔG〉 for μSBSs in \(\mathcal {M}_{\text {PoP}}\) reached from synonymous codons (syn) or from the wild-type codon (used), according to the position of the substituted base in the codon (I, II and III), and according to whether the position-dependent frequency of translation errors is taken into account (translation) or not (random). σ is the standard deviation of the ΔΔG distribution: σ2(ΔΔG)=σ2(ΔΔGused)+σ2(ΔΔGsyn)

From: Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

 

(〈ΔΔGsyn〉−〈ΔΔGused〉)/σ

 

All (%)

Core (%)

Surface (%)

I

3

− 2

11

II

7

6

6

III

11

9

8

Random

7

3

9

Translation

6

4

7