Table 7 Difference between 〈ΔΔG〉 for μSBSs in \(\mathcal {M}_{\text {PoP}}\) reached from synonymous codons (syn) or from the wild-type codon (used), according to the position of the substituted base in the codon (I, II and III), and according to whether the position-dependent frequency of translation errors is taken into account (translation) or not (random). σ is the standard deviation of the ΔΔG distribution: σ2(ΔΔG)=σ2(ΔΔGused)+σ2(ΔΔGsyn)