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Fig. 2 | BMC Biology

Fig. 2

From: Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate

Fig. 2

Affinities of adenylation domains from dinoflagellates show the importance of glycine as a substrate for biosynthesis of specialized toxin secondary metabolites. A molecular phylogenetic tree of adenylation domains indicates protein diversification in Symbiodiniaceae and A. gibbosum. Green- and orange-shaded regions indicate adenylation-domain affinities in Symbiodiniaceae and A. gibbosum, respectively. The Symbiodiniaceae can incorporate glycine (green box) during specialized toxin secondary metabolite biosynthesis such zooxanthellatoxin B (ZT-B) and zooxanthellamide D (ZAD-D), whereas A. gibbosum does not utilize glycine, yielding the simple nitrogen-lacking polyketides, amphidinin A and amphidinolide P. A. gibbosum adenylation sequences are denoted in blue. Red dots indicate a posterior probability ≥ 0.75 using Bayesian inference

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