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Fig. 2 | BMC Biology

Fig. 2

From: Population structure and pharmacogenomic risk stratification in the United States

Fig. 2

Pharmacogenomic variation in the US. Genome-wide average allele frequencies (a), group-specific allele frequency differences (b), and heterozygosity fractions (c) are shown for PGx variants (red) compared to non-PGx variants (blue). df Fixation index (FST; y-axis) and allele frequency differences (x-axis) for pairs of SIRE groups. Statistically significant PGx allele frequency differences are highlighted in black. g Heatmap showing group-specific allele frequencies for significantly diverged PGx variants. h Multi-dimensional scaling (MDS) plot showing the relationship among individual genomes as measured by PGx variants alone. Each dot is an individual HRS participant genome, and genomes are color-coded by participants SIRE. i The correspondence between SIRE groups and PGx groups defined by K-means clustering on the results of the MDS analysis. Data shown here correspond to SIRE groups; analogous results for GA groups are shown in Supplementary Figure 4 (see Additional file 1: Figure S4)

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