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Fig. 5 | BMC Biology

Fig. 5

From: Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

Fig. 5

Decreased synaptic GluN2A and GluN2B expression accompanied with reduced GluN2B Y1472 phosphorylation in NSPA-KO hippocampus. a Total levels of synaptic proteins were analyzed by immunoblot in whole hippocampal lysates of WT and NSPA-KO mice; synaptic proteins levels were not different (mean ± SEM; n = 3 per group; n.s, non-statistical differences, t-test). b Hippocampal PSDs show lower levels of GluN2A and GluN2B in NSPA-KO compared with WT mice (mean ± SEM; n = 4 per group; *P < 0.05, **P < 0.01, t-test). c Immunoblot analysis and relative intensity of GluN2B Tyr1472P versus total GluN2B of hippocampal P2 fractions show lower levels of GluN2B Tyr1472P in NSPA-KO compared with WT mice (mean ± SEM; n = 8; **P < 0.01, t-test). Source data values are included in Additional file 2

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