Fig. 5
ARTD10 inhibition reduces the proportion of the inactivating Kv1.1 current and enhances spontaneous excitation in hippocampal neurons. a Left, whole cell currents of mouse hippocampal neurons in the presence of tetrodotoxin with and without an inhibitor of ARTD10 (OUL35). Right, bar graphs representing Isteady-state/Ipeak (Is/Ip) and peak current amplitudes. b Resting membrane potential (RMP) and spontaneous spikes/s from control and OUL35 treated hippocampal neurons. *p < 0.05 (Student’s t test). c Top, examples of current clamp recordings of control (left) and OUL35 treated hippocampal neurons (right). Some of the cells had spontaneous APs (red), and some not (blue). Bottom, pie chart illustrating the proportion of cells with or without spontaneous APs. *p < 0.05 (Fisher’s exact test)