Fig. 2
From: Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences
Benchmarking oA3G-BE3 against YE1-BE3 at diverse targets. Heatmaps showing editing rates at 8 target sites, including the three used in Fig. 1 (a–h), and Western blot measuring editor expression (i). These sites collectively present editing motifs with a wide range of complexity. EMX1-1 and EMX1-2 are two adjacent sites on the same gene. CACNA1A and ITPR1 have naturally occurring pathogenic C>T mutations at the indicated C. Arrows indicate the intended target C for oA3G-BE3. Data are from triplicate transfections