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Fig. 6 | BMC Biology

Fig. 6

From: PHOSPHO1 is a skeletal regulator of insulin resistance and obesity

Fig. 6

Osteocalcin-independent mechanism of PHOSPHO1-regulated energy metabolism. To assess the relative change in Esp mRNA expression in primary calvarial osteoblasts, RT-qPCR was conducted to compare a primary WT and Phospho1−/− osteoblasts and b Phospho1−/− osteoblast transfected with empty (EV) or overexpressing (OE) vectors. c, d Osteocalcin content of serum from WT and Phospho1−/− mice at 60 and 120 days of age. Data are represented as mean ± S.E.M n = 5–6 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001 and the data were assessed as follows: ac Two-tailed Mann–Whitney test or two-tailed unpaired t test

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