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Fig. 3 | BMC Biology

Fig. 3

From: Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Fig. 3

Global stabilization of β-catenin leads to impaired placental development with excessive TGC differentiation. a Average litter sizes of WT females mated with Ctnnb1f(EX3)/+ and Prm-cre; Ctnnb1f(EX3)/+ males, respectively. *P < 0.05. b Genotyping of the newborns from WT females mated with Prm-cre; Ctnnb1f(EX3)/+ males. c Average embryo degeneration rate of WT females mated with Ctnnb1f(Ex3)/+ and Prm-cre; Ctnnb1f(EX3)/+ males, respectively, at E11.5. *P < 0.05. d Genotyping of the remaining survived embryos from WT female mated with Prm-cre; Ctnnb1f(EX3)/+ male mice at E11.5. e HE and CK staining of Ctnnb1f(EX3)/+ and Ctnnb1fΔ/+ placental sections at E9.5. In ad, numbers within and above the bars indicated the number of pregnant mice and embryos examined, respectively. Images in e are representatives of at least three independent experiments. Al, allantois; Dec, decidua; Cp, chorionic plate; Em, embryo; Sp, spongiotrophoblast; TGC, trophoblast giant cell. Scale bar, 100 μm

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