Fig. 2

CLANS analysis of EVE domains. A 2D projection of CLANS clustering analysis of 8403 representative EVE domain sequences. Each sequence is depicted by a dot, and sequence similarity detected by BLAST is indicated by a line, colored in shades of gray according to the BLAST p value. Four primary clusters were observed, marked with colors which match colored lines extending toward the pie chart which corresponds to the cluster. The protein sequences used for the CLANS analysis are available as Additional file 2: Dataset 1