Fig. 4
From: The CBP KIX domain regulates long-term memory and circadian activity
CBPKIX/KIX mice show transcriptional dysregulation of learning-responsive genes. a Heat map depicting color-coded expression of the top 12 upregulated or downregulated genes responsive to learning (left) which fail to be appropriately regulated following learning in CBPKIX/KIX mice (right). Left: Genes depicted show differential expression between homecage wildtype mice with wildtype mice after learning in the Morris Water Maze (MWM) and contextual fear conditioning (CFC) training. Right: The same genes exhibit differential expression between trained wild type mice and trained CBPKIX/KIX mice. Expression values depicted represent the scaled log of RUV-normalized counts per million. As RUV normalization differed between differential expression analyses, scaling was applied independently for each analysis. b CBPKIX/KIX mice showed significantly decreased expression of circadian and memory related genes after learning (MWM and FC). Unpaired t test, Per1: p = 0.0068; Per2: p = 0.0019; Nr4A1: p = 0.0039; FosB: p = 0.0034; and JunB: p = 0.0190