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Fig. 5 | BMC Biology

Fig. 5

From: The CBP KIX domain regulates long-term memory and circadian activity

Fig. 5

Male and female CBPKIX/KIX mice have increased free-running periods compared to wildtype littermates. a CBPKIX/KIX mice have delayed activity onset and peak activity in 12-h:12-h LD compared to wildtype littermates. Each data point represents 1 h of binned activity data. Mixed design ANOVA: Significant time × genotype interaction between CBPKIX/KIX and WT mice (F(23,644) = 8.26, p = 0.00003). b There are no significant differences in total activity levels between wildtype and CBPKIX/KIX mice [t(28) = 0.03183, p = 0.9748]. c No significant differences were observed with the light and dark phase activity analyzed independently [two-way ANOVA: no significant Genotype × Light/Dark interaction, F(1, 56) = 0.02275, p = 0.88]. d CBPKIX/KIX male and female mice display longer free-running circadian periods in constant darkness compared to wildtype littermates (t (29) = 6.550, p < 0.0001). e Sex had no effect on circadian period of WT or CBPKIX/KIX mice [Two-way ANOVA: Sex × Genotype interaction (F(1, 27) = 0.9139, p = 0.3476), Main effect of genotype, F(1, 27) = 38.24, p < 0.0001. f Representative actograms for males (left) and females (right)

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