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Table 1 Highest confidence (95%) changes in homecage gene expression in CBPKIX/KIX mice

From: The CBP KIX domain regulates long-term memory and circadian activity

Gene symbol

Confidence

Probe set

Molecular role

Wt(Log2)

% change

Downregulated genes

 Slc25a34

0.995

1455506_at

Mitochondrial solute carrier protein

7.99

− 43%

 Papss2##

0.995

1421987_at

Sulfate Adenylyltransferase, cysteine synthesis

6.89

− 42%

 Efcab6

0.993

1453766_a_at

Calcium-binding transcriptional co-repressor

8.02

− 25%

 Cbp

0.993

1459804_at

Transcriptional co-activator CBP, KIX domain

8.41

− 37%

 Nts

0.991

1422860_at

Neuropeptide

10.73

− 31%

 Lipm#

0.991

1430550_at

Triglyceride hydrolysis

5.38

− 40%

 Cenpa

0.991

1450842_a_at

Double-strand break repair, centromere organization

6.75

− 29%

 Pmch

0.988

1429361_at

Neuropeptide

7.33

− 24%

 Fos

0.988

1423100_at

DNA-binding transcription factor

9.55

− 33%

 Crhbp

0.988

1436127_at

Regulator of hormone signaling

11.03

− 20%

 Ccl6#

0.988

1420249_s_at

Cytokine, inflammatory response

6.79

− 25%

 Cth

0.987

1426243_at

Cysteine-Protein Sulfhydrase, cysteine synthesis

7.89

− 24%

 Nqo1

0.98

1423627_at

Positive regulator of translation; quinone detoxification

9.27

− 20%

 Tbx1

0.975

1425779_a_at

DNA-binding transcription factor

5.65

−25%

 Spata13

0.975

1454656_at

Guanine nucleotide exchange factor

9.44

− 19%

 Rec8

0.975

1419147_at

Meiotic chromatid cohesion

6.68

− 26%

 Bglap

0.972

1449880_s_at

Osteogenic marker

7.13

− 38%

 Cyp11a1#

0.965

1448804_at

Steriod hormone metabolism, cholesterol metabolism

7.43

− 28%

 Pdlim2

0.962

1423946_at

Negative regulator of NFkappa-B and STAT signaling

9.46

− 21%

 Zdbf2

0.955

1456783_at

Unknown

10.51

− 16%

 Pcsk1

0.955

1421396_at

Pro-neuropeptide cleavage

7.91

− 24%

 Gpnmb

0.955

1448303_at

Transmembrane glycoprotein

7.84

− 18%

 Dusp10

0.955

1417163_at

Phosphatase

8.96

− 17%

 Dbp#

0.955

1418174_at

DNA-binding transcription factor

10.63

− 24%

 Plcd1

0.952

1448432_at

Ca2+-dependent phospholipase, phosphotidyl inositol-signaling

8.69

− 18%

 Mmel1

0.952

1449432_a_at

Membrane metalloprotease

5.17

− 28%

 Cort

0.952

1449820_at

Neuropeptide

9.01

− 30%

Upregulated genes

 Ifi27l2a

0.995

1427747_a_at

Interferon, alpha-inducible protein 27 like 2A

2.19

358%

  1. #A second probe set for this gene was also present in the 80% confidence probe set list
  2. ##Two additional probe sets for this gene were present in the 80% confidence probe set list