Fig. 4

Characteristics of deletions change with age, but not the expression of Polg^D181A. a Density plot of deletion sizes for WT (grey) and Polg^D181A (red) for 10- (dotted line), 50- (dashed line), and 80-week-old (full line) mice. b The shortest average distance from 5′ and 3′ deletion breakpoint pairs to a direct repeat pair in the mitochondrial genome for the observed deletions (darker colour) and a random in silico generated deletion length-matched library (lighter colour) for both WT (left, in grey) and Polg^D181A (right, in red) using pooled data from all ages and brain regions examined for each genotype. p values of two-sided t tests are shown. c Needle identity score calculated in a ± 10 bp window at the 5′ and 3′ deletion breakpoints as a function of deletion size after pooling of WT and Polg^D181A samples. Correlation for each age is indicated by the full lines and correlation data indicated in the same colour code