Fig. 4.

Associations between levels of Serpin E1, IL-8, MIF, and PDGF-AA and survival in breast cancer patients. The METABRIC dataset was used to assess the association between expression levels of Serpin E1 (a), IL-8 (b), PDGF-AA (c), MIF (d) and the mean signature levels of all 4 factors (median of the mean of normalized expression levels of the four factors) (e), with 10-year survival. Protein levels were classified as higher or lower than the median, and the association to 10-year survival was assessed by the Kaplan-Meier analysis (n = 952 per group). p value was calculated using two-sided log rank test